Advanced Glycation End Products

Advanced glycation end products (AGEs) are proteins and lipids (fats) that go through a chemical alteration called glycation when they are exposed to sugars, a process that occurs naturally in the body. "However, processed foods and foods cooked at high temperatures are extremely high in AGEs, which can lead to a dangerous overabundance in the body." (Source: Medical University of South Carolina).

According to Dr. David Turner, associate professor at the Medical University of South Carolina explores he impact of AGEs on the body, "which have been linked to many chronic diseases, including cancer, build up in the body from birth due to normal metabolism but are often higher in those eating the high-fat, high-sugar, highly processed foods characteristic of the Western diet. AGE levels have been linked to lifestyle, such as diet and exercise, and lifestyle changes were shown in previous studies at MUSC to drive a reduction in AGEs in breast cancer patients" (Source: Medical University of South Carolina). 



Most recently, Bobzilla has funded research at the MUSC Hollings Cancer Center to conduct a study to determine whether popular dog foods are causing cancer. Dr. Turner and his team have estimated that "dog food is about 100 times higher in AGEs than human food,”  and that they "have seen the impacts that AGEs have on humans, yet we are giving our pets 100 times more."   Further, he concludes that "In a little over a decade, Golden Retrievers have lost about five years off their life expectancy. We believe that processed pet food consumption has contributed to this concerning statistic.". Learn more here and watch the videos below.

Do you know what AGEs are?

The Role of Dietary Advanced Glycation End Products in Cancer Development

 More Research:

  • AGEs (Advanced Glycation End Products: "(AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. They are a bio-marker implicated in aging and the development, or worsening, of many degenerative diseases, such as diabetes, atherosclerosis, chronic kidney disease."  Feeding your dog kibble means you are feeding them AGEs.  Raw or home-cooked is the way to go. 
  • How Can Diet Affect the Accumulation of Advanced Glycation End-Products in the Human Body?: AGEs accumulate in the bodies of both humans and dogs.  This article published by the NIH demonstrates the impact of diet on AGE accumulation in humans, which is comparable to our dogs.  Whole foods and low glycemic is the way to go!
  • Its Maillard, Not Mallard: The Maillard reaction. refers to the binding of simple sugars including glucose, fructose and galactose with the amino acids in protein found in dog food and can result in nutritional deficiencies despite claims of being "complete" or "balanced."  Further, these Maillard compounds are not stable and rearrange themselves and then turn into Advanced Glycation End (AGEs) products, which are linked to chronic inflammatory diseases. 
  • Urinary Excretion of Advanced Glycation End Products in Dogs and Cats: This study examines the relationship between dietary AGEs and the urinary excretion of AGEs, dogs that were raw fed excreted less AGEs than kibble fed dogs because raw food is low in AGEs. A diet low in AGEs = Healthier dog.  (Read more on our blog)  


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