Advanced Glycation End Products
Advanced Glycation Endproducts (AGEs) are proteins or lipids that become bonded to a sugar molecule without enzymatic regulation, a biochemical process in which enzymes are catalyzed and regulated by the body. AGEs are found in both human and dog food. As a result, AGE’s become activated within the cells of the body and, modify proteins and DNA function, which has been linked to metabolic disease, cardiovascular disease, non-alcoholic fatty liver disease, obesity, and type 2 diabetes.
Dr. David Turner, associated professor at the Medical University of South Carolina explores he impact of AGEs on the body, "which have been linked to many chronic diseases, including cancer, build up in the body from birth due to normal metabolism but are often higher in those eating the high-fat, high-sugar, highly processed foods characteristic of the Western diet. AGE levels have been linked to lifestyle, such as diet and exercise, and lifestyle changes were shown in previous studies at MUSC to drive a reduction in AGEs in breast cancer patients. Click here to learn more.
Most recently, Bobzilla has funded research at the MUSC Hollings Cancer Center to conduct a study to determine whether popular dog foods are causing cancer. Dr. Turner and his team have estimated that "dog food is about 100 times higher in AGEs than human food,” and that they "have seen the impacts that AGEs have on humans, yet we are giving our pets 100 times more." Further, he concludes that "In a little over a decade, Golden Retrievers have lost about five years off their life expectancy. We believe that processed pet food consumption has contributed to this concerning statistic.". Learn more here and watch the videos below.
Do you know what AGEs are?
The Role of Dietary Advanced Glycation End Products in Cancer Development
- How Can Diet Affect the Accumulation of Advanced Glycation End-Products in the Human Body?: AGEs accumulate in the bodies of both humans and dogs. This article published by the NIH demonstrates the impact of diet on AGE accumulation in humans, which is comparable to our dogs. Whole foods and low glycemic is the way to go!